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Table 3 Associations of clinical and research diagnosis of ADHD with cardiovascular disorders (CVDs) and metabolic disorders, as hazard ratios with 95% confidence intervals

From: Attention-deficit/hyperactivity disorder symptoms and subsequent cardiometabolic disorders in adults: investigating underlying mechanisms using a longitudinal twin study

 

CVD

Metabolic disorders

Clinical diagnosis

 Adjustment for birth year and sexa

2.34 (1.47, 3.74), p < 0.001

2.19 (1.20, 4.00), p = 0.011

 Additional adjustment for covariatesb

1.64 (0.91, 2.94), p = 0.097

1.75 (0.88, 3.45), p = 0.107

Research diagnosis

 Adjustment for birth year and sexa

1.61 (1.23, 2.11), p < 0.001

1.77 (1.27, 2.46), p < 0.001

 Additional adjustment for covariatesb

1.09 (0.77, 1.54), p = 0.629

1.00 (0.64, 1.55), p = 0.999

  1. aN = 10,394, with CVD N = 1313, with metabolic disorders N = 728
  2. bCovariates: educational attainment, lifestyle, and psychiatric disorders, N = 8305 for the association with CVD, N with CVD is 1007; N = 8434 for the association with metabolic disorders, N with metabolic disorders is 587, analysis for the association with metabolic disorders was not adjusted for BMI
  3. Bolded estimates are statistically significant, p-values less than 0.001 or 0.05