Fig. 6

Clinical relevance of PScore in melanoma cohorts treated with ICB therapy. A Heatmap showing expression of 31 PRGs and corresponding clinical features of our in-house data; red and blue denote high and low expression, respectively. The horizontal axis represents the patients, and the y-axis represents the PRGs. Legends on the right, including age, sex, subtype, immune response, PScore, and PScore group, are annotated above the heatmap. B Boxplots show PScore in different immune responses of in-house data, PRJEB23709 and GSE35640. The x-axis represents the immune response (NR, nonresponder; R, responder). C Bar plots show chi-square test results of immune response and PScore groups of in-house data, PRJEB23709 and GSE35640. The x-axis represents the PScore group, the y-axis represents the proportion of patients, and the colors represent the immune response. D–F KM curves for PFS or OS of in-house data, GSE91061, PRJEB23709, phs000452.v3, TCGA-SKCM patients with immunotherapy and proteomics data. The x-axis represents survival time (unit: year or month), and the y-axis represents OS or PFS rate. G Boxplots show PScore in different immunotherapy responses of proteomics data. The x-axis represents the immune response, and the y-axis represents PScore. H Bar plot showing the chi-square test results of immunotherapy response and PScore groups of proteomics data. The x-axis represents the PScore group, and the y-axis represents the proportion of patients