Fig. 3

PCR validation of data from the EV RNA-seq analysis and their association with uterine artery doppler pulsatility index (PI). Samples from women with preeclampsia (PE)/normal pregnancy (NP), n=28/n=32 at 22–24 weeks and n=20/n=32 at 36–38 weeks, respectively, were used. A Validation of the mitochondrial RNAs MT-TA, MT-ND2 and MT-CYB at weeks 22–24 and 36–38 between women who subsequently developed PE and controls (NP), adjusted for age and BMI. B Scatter plot showing the correlation between mitochondrial RNAs and uterine artery PI at weeks 22–24 and 36–38 between women who subsequently developed PE and controls (NP). C Validation of the platelet-derived RNAs PF4, PPBP and CLU at weeks 22–24 and 36–38 between women who subsequently developed PE and controls (NP), adjusted for age and BMI. r=correlation coefficient, *p-value<0.05, ** p<0.01, ***p<0.001