Fig. 5From: Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory studyAverage normalized counts for RNAs coding for protein used as EV markers (from MISEV2018 standards of EV research) in the controls from the RNA-seq analysis. Category 1, use for all EVs: Transmembrane or GPI-anchored proteins associated to plasma membrane and/or endosomes, 1a non-tissue specific, 1b tissue specific; Category 2, use for all EVs: Cytosolic proteins recovered in EVs, 2a with lipid or membrane protein-binding ability, 2b promiscuous incorporation in EVs (and possibly exomeres); Category 3, use for all EVs as purity control, major components of non-EV co-isolated structures: 3a lipoproteins (produced by liver, abundant in plasma, serum), 3b protein and protein/nucleic acid aggregates; Category 4, use for subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state, Transmembrane, lipid-bound and soluble proteins associated to other intracellular compartments than PM/endosomes: 4a nucleus, 4b mitochondrial, 4c secretory pathway (endoplasmic reticulum, Golgi apparatus), 4d others (autophagosomes, cytoskeleton); Category 5, use for functional component of EVs: need to determine the mode of association with EVs: 5a Cytokines and growth factors, 5b adhesion and extracellular matrix proteinsBack to article page