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Table 1 Clinical and demographic characteristics of the study population selected from the STORK cohort

From: Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study

Criteria

RNA-seq

EV validation

Plasma validation

Leukocyte validation

NP (n=7)

Preeclampsia (n=7)

P-value

NP (n=32)

Preeclampsia (n=28)

P-value

NP (n=35)

Preeclampsia (n=35)

P-value

NP (n=215)

Preeclampsia (n=38)

P-value

Age (years)

29 ± 3

29 ± 4

0.653

32 ± 4

30 ± 3

0.037

32 ± 4

30 ± 4

0.019

32 ± 4

30 ± 4

0.001

Gestational age at delivery (week)

40 ± 1

39 ± 2

0.228

40 ± 1

39 ± 3

0.002

40 ± 1

39 ± 3

0.001

40 ± 1

39 ± 3

<0.001

Multiparous n (%)

3 (43)

2 (29)

0.577

15 (47)

8 (29)

0.187

16 (46)

10 (29)

0.138

110 (47)

11 (29)

0.035

Uterine artery PI

 22–24 weeks

0.74 (0.52, 1.06)

1.05 (0.80, 1.92)

0.151

0.79 (0.72, 0.94)

0.99 (0.79, 1.16)

0.045

0.81 (0.70, 0.97)

1.05 (0.79, 1.17)

0.006

0.83 (0.72, 0.99)

1.01 (0.79, 1.17)

0.007

 36–38 weeks

0.81 (0.68, 1.24)

0.87 (0.73, 1.03)

1.000

0.72 (0.60, 0.86)

0.84 (0.68, 1.09)

0.060

0.72 (0.59, 0.85)

0.84 (0.69, 1.08)

0.021

0.72 (0.60, 0.84)

0.84 (0.69, 1.08)

0.007

BMI (kg/m2)

 14–16 weeks

23.2 (21.2, 23.6)

23.1 (20.4, 26.6)

0.668

23.9 (21.2, 26.8)

28.1 (24.2, 30.6)

0.002

23.6 (21.2, 26.4)

27.5 (22.5, 29.8)

0.007

23.5 (21.3, 25.4)

27.4 (23.1, 29.9)

<0.001

 22–24 weeks

23.8 (22.4, 25.1)

23.8 (21.7, 26.6)

0.886

24.9 (22.4, 27.7)

29.5 (25.4, 32.7)

0.002

24.8 (22.4, 27.6)

28.1 (23.2, 31.9)

0.011

24.8 (22.5, 26.8)

29.0 (23.8, 32.1)

<0.001

 30–32 weeks

25.0 (23.4, 25.8)

25.1 (23.4, 28.3)

0.886

27.2 (23.9, 28.8)

31.7 (28.5, 33.4)

<0.001

26.4 (23.8, 28.8)

31.3 (25.6, 33.3)

0.004

26.1 (23.7, 28.3)

31.2 (26.0, 33.3)

<0.001

 36–38 weeks

26.1 (24.0, 26.7)

27.6 (24.1, 29.7)

0.199

27.8 (25.2, 30.0)

33.7 (28.2, 35.0)

0.001

27.4 (25.1, 30.0)

31.8 (27.1, 34.8)

0.006

27.2 (24.8, 29.5)

32.2 (27.3, 34.8)

<0.001

Systolic BP (mmHg)

 14.16 weeks

110 (110, 120)

110 (109, 120)

0.836

110 (105, 116)

115 (110, 120)

0.020

110 (105, 115)

115 (110, 120)

0.013

110 (100, 119)

115 (110, 120)

0.002

 22–24 weeks

110 (110, 120)

110 (104, 121)

0.836

110 (103, 119)

120 (104, 120)

0.136

110 (102, 115)

118 (105, 120)

0.119

110 (100, 115)

115 (104, 120)

0.046

 30–32 weeks

120 (105, 125)

110 (105, 120)

0.620

110 (106, 120)

120 (110, 130)

0.064

110 (105, 120)

120 (110, 125)

0.102

110 (105, 120)

120 (110, 126)

0.002

 36–38 weeks

118 (111, 121)

125 (120, 150)

0.101

115 (100, 120)

130 (118, 138)

<0.001

115 (100, 120)

130 (120, 139)

<0.001

110 (105, 120)

130 (120, 138)

<0.001

Diastolic BP (mmHg)

 14.16 weeks

65 (60, 75)

70 (69, 73)

0.366

68 (60, 70)

70 (65, 80)

0.062

65 (60, 70)

70 (65, 79)

0.016

70 (60, 70)

70 (65, 80)

0.004

 22–24 weeks

70 (60, 70)

70 (60, 80)

0.836

65 (60, 70)

70 (60, 80)

0.035

75 (60, 70)

70 (60, 80)

0.020

65 (60, 70)

70 (60, 80)

0.001

 30–32 weeks

70 (60, 80)

70 (65, 80)

0.902

70 (60, 75)

75 (70, 84)

0.011

70 (60, 75)

70 (65, 80)

0.010

70 (60, 70)

73 (70, 80)

<0.001

 36–38 weeks

73 (68, 80)

80 (70, 95)

0.181

70 (65, 80)

90 (78, 93)

<0.001

70 (65, 80)

85 (76, 94)

<0.001

70 (69, 80)

85 (78, 93)

<0.001

MAP (mmHg)

 14–16 weeks

80 (77, 90)

83 (82, 88)

0.471

81 (76, 85)

86 (80, 90)

0.018

80 (75, 85)

84 (80, 90)

0.005

80 (75, 85)

85 (80, 90)

<0.001

 22–24 weeks

83 (77, 87)

84 (75, 93)

0.999

80 (77, 86)

85 (80, 93)

0.026

80 (77, 85)

85 (79, 93)

0.016

80 (73, 85)

83 (79, 93)

0.001

 30–32 weeks

83 (77, 95)

83 (77, 93)

0.949

83 (77, 90)

89 (82, 99)

0.018

83 (77, 90)

87 (82, 95)

0.019

82 (77, 87)

87 (83, 95)

<0.001

 36–38 weeks

88 (82, 94)

95 (87, 113)

0.132

84 (80, 92)

103 (90,108)

<0.001

84 (79, 92)

100 (90, 108)

<0.001

85 (80, 93)

100 (90, 108)

<0.001

  1. Data given as mean ± SD when normally distributed and median (25th, 75th percentile) when not normally distributed
  2. NP Normal pregnancy, EV, Extracellular vesicles, BMI Body mass index, MAP Mean arterial pressure, BP Blood pressure, PI Pulsatility index