Group (cases/ref.) | Subgroup (cases/ref.) | DFS/OS | HR | LCI | UCI | P value |
---|---|---|---|---|---|---|
Postoperative ctDNA (225/5) | OS | 6.44 | 3.31 | 12.54 | < 0.001 | |
Postoperative ctDNA (225/5)a | OS | 5.59 | 2.84 | 10.98 | < 0.001 | |
Postoperative ctDNA (225/5)b | OS | 5.08 | 2.58 | 9.99 | < 0.001 | |
Postoperative ctDNA (1051/14) | PFS | 6.52 | 5.08 | 8.36 | < 0.001 | |
Postoperative ctDNA (1051/14)a | DFS | 5.88 | 4.51 | 7.67 | < 0.001 | |
Postoperative ctDNA (1051/14)b | DFS | 5.85 | 4.46 | 7.67 | < 0.001 | |
Postoperative ctDNA (538/5)c | DFS | 3.87 | 2.57 | 5.83 | < 0.001 | |
Postoperative ctDNA by PSM (106/5) | DFS | 3.96 | 2.19 | 7.16 | < 0.001 | |
Age | < 60 years (270/6) | DFS | 8.01 | 4.48 | 14.32 | < 0.001 |
60–69 years (194/5) | DFS | 5.28 | 2.97 | 9.37 | < 0.001 | |
70–75 years (69/6) | DFS | 7.53 | 2.57 | 22.04 | 0.001 | |
> 75 years (45/5) | DFS | 2.40 | 0.94 | 6.18 | 0.090 | |
Gender | Female (260/6) | DFS | 6.44 | 3.30 | 12.57 | < 0.001 |
Male (318/6) | DFS | 5.52 | 3.61 | 8.44 | < 0.001 | |
Smoking history | With (299/6) | DFS | 5.66 | 3.47 | 9.24 | < 0.001 |
Without (358/5) | DFS | 5.62 | 3.69 | 8.55 | < 0.001 | |
Tumor size | ≤ 2 cm (188/3) | DFS | 8.40 | 3.21 | 21.95 | < 0.001 |
2.1–3 cm (157/4) | DFS | 7.66 | 3.87 | 15.15 | < 0.001 | |
3.1–5 cm (133/4) | DFS | 4.98 | 2.63 | 9.44 | < 0.001 | |
> 5 cm (35/4) | DFS | 1.11 | 0.32 | 3.82 | 0.913 | |
Pathological type | AD (534/10) | DFS | 6.93 | 4.73 | 10.17 | < 0.001 |
SCC (161/10) | DFS | 3.56 | 2.06 | 6.15 | < 0.001 | |
Other (43/8) | DFS | 3.04 | 1.26 | 7.36 | 0.022 | |
T stage | T1 (298/7) | DFS | 8.56 | 4.58 | 15.99 | < 0.001 |
T2 (235/7) | DFS | 4.74 | 2.98 | 7.53 | < 0.001 | |
T3&T4 (87/7) | DFS | 2.16 | 1.09 | 4.28 | 0.043 | |
N stage | N0 (419/8) | DFS | 4.82 | 2.72 | 8.54 | < 0.001 |
N1 (97/7) | DFS | 4.69 | 2.45 | 8.96 | < 0.001 | |
N2 (114/8) | DFS | 3.62 | 2.10 | 6.25 | < 0.001 | |
Pathological stage | Stage I (376/9) | DFS | 5.50 | 2.77 | 10.92 | < 0.001 |
Stage II (160/9) | DFS | 4.83 | 2.68 | 8.68 | < 0.001 | |
Stage III (153/9) | DFS | 2.80 | 1.79 | 4.37 | < 0.001 | |
ACT | With (310/10) | DFS | 4.06 | 2.70 | 6.09 | < 0.001 |
Without (341/8) | DFS | 10.48 | 6.65 | 16.52 | < 0.001 |