Table 3 Liner regression analyses of GDM (1999 WHO) with child amino acids at mid-childhood

From: Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort

	Raw model		Adjusted model 1		Adjusted model 2
Amino acids	Effect size (95% CI)	p	Effect size (95% CI)	p	Effect size (95% CI)	p
Alanine	− 0.20 (− 0.45, 0.04)	0.11	− 0.16 (− 0.42, 0.09)	0.21	− 0.14 (− 0.39, 0.11)	0.28
Glutamine	− 0.10 (− 0.35, 0.15)	0.42	− 0.12 (− 0.36, 0.13)	0.35	− 0.10 (− 0.35, 0.15)	0.44
Glycine	− 0.18 (− 0.43, 0.06)	0.14	− 0.20 (− 0.46, 0.05)	0.12	− 0.20 (− 0.46, 0.06)	0.13
Histidine	0.14 (− 0.11, 0.38)	0.28	0.14 (− 0.11, 0.40)	0.27	0.18 (− 0.08, 0.44)	0.18
Isoleucine	0.10 (− 0.15, 0.35)	0.43	0.14 (− 0.12, 0.39)	0.30	0.14 (− 0.12, 0.39)	0.30
Leucine	0.30 (0.05, 0.54)	0.02	0.29 (0.03, 0.54)	0.03	0.28 (0.02, 0.53)	0.03
Valine	0.26 (0.01, 0.51)	0.04	0.27 (0.01, 0.52)	0.04	0.27 (0.01, 0.52)	0.04
Total BCAAs	0.26 (0.01, 0.50)	0.04	0.26 (0.01, 0.52)	0.04	0.26 (0.01, 0.52)	0.04
Phenylalanine	0.06 (− 0.18, 0.30)	0.64	0.09 (− 0.17, 0.34)	0.50	0.11 (− 0.13, 0.36)	0.37
Tyrosine	− 0.00 (− 0.25, 0.24)	0.99	− 0.06 (− 0.31, 0.20)	0.67	− 0.03 (− 0.27, 0.21)	0.82
Aromatic AA	0.03 (− 0.21, 0.27)	0.81	0.01 (− 0.24, 0.26)	0.94	0.04 (− 0.20, 0.28)	0.74

Adjusted model 1 covariates: maternal age, child ethnicity, mothers’ highest education, parity, family history of diabetes, child sex, and pre-pregnancy body mass index
Adjusted model 2 covariates: Model 1 further added in child year-6 body mass index z-score and age
A significant P-value (two-tailed) was defined as < 0.05

Back to article page

ISSN: 1741-7015

Contact us

Submission enquiries: bmcmedicineeditorial@biomedcentral.com
General enquiries: info@biomedcentral.com