Fig. 3

Genetic and nonshared environmental correlations between BMI trajectories and protein levels in the FinnTwin12 sample. A Among the 53 heritable proteins for which associations with BMI were significant, bivariate twin models were conducted to dissect the nature of the associations. B Genetic and nonshared environmental correlations were also quantified in the association between slope of BMI and protein levels; lines correspond to confidence intervals at the 95% threshold, arrows point to estimates obtained by adjusting protein levels by BMI at blood sampling prior to bivariate twin modeling rather than using BMI intercept as a covariate (pink). C The direction of the genetic correlations observed between BMI at blood sampling and protein levels were consistent with the t-values observed by crossing the PRS of BMI with protein levels. BMI: body mass index. PRS: polygenic risk score