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Table 2 Mixed-effects model-derived estimates of proteins significantly associated with body mass index at blood sampling in FinnTwin12 participants

From: Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

  

P-value

Protein description

UniProt ID

Estimate

SE

t-value

Nominal

Bonferroni

Proteoglycan 4

Q92954

0.46

0.03

13.6

4.70E − 37

2.10E − 34

Complement factor H

P08603

0.33

0.04

9.1

9.00E − 19

4.00E − 16

Serum amyloid P-component

P02743

0.34

0.04

9.0

1.70E − 18

7.60E − 16

C-reactive protein

P02741

0.31

0.04

8.5

1.30E − 16

5.60E − 14

Secreted phosphoprotein 24

Q13103

− 0.30

0.04

− 8.1

3.40E − 15

1.50E − 12

Complement component C7

P10643

− 0.28

0.04

− 7.5

2.30E − 13

1.00E − 10

Sex hormone-binding globulin

P04278

− 0.33

0.05

− 7.2

1.50E − 12

6.60E − 10

Antithrombin-III

P01008

− 0.25

0.04

− 6.7

4.30E − 11

1.90E − 08

Complement factor I

P05156

0.23

0.04

6.5

2.20E − 10

9.80E − 08

Complement C4-A

P0C0L4

0.23

0.04

6.3

6.50E − 10

2.90E − 07

C4b-binding protein alpha chain

P04003

0.23

0.04

6.2

1.20E − 09

5.40E − 07

Corticosteroid-binding globulin

P08185

− 0.24

0.04

− 5.9

6.20E − 09

2.70E − 06

Protein S100-A8

P05109

0.21

0.04

5.8

9.30E-09

4.10E − 06

Fumarylacetoacetase

P16930

0.20

0.03

5.8

1.40E − 08

6.10E − 06

Apolipoprotein B-100

P04114

0.21

0.04

5.7

2.00E − 08

8.60E − 06

Inter-alpha-trypsin inhibitor heavy chain H2

P19823

− 0.20

0.04

− 5.6

2.80E − 08

1.20E − 05

Pancreatic alpha-amylase

P04746

− 0.20

0.04

− 5.6

3.40E − 08

1.50E − 05

72 kDa type IV collagenase

P08253

− 0.20

0.04

− 5.5

6.50E − 08

2.80E − 05

Contactin-1

Q12860

− 0.20

0.04

− 5.4

8.50E − 08

3.70E − 05

Interleukin-1 receptor accessory protein

Q9NPH3

− 0.20

0.04

− 5.4

1.10E − 07

4.70E − 05

Apolipoprotein D

P05090

− 0.20

0.04

− 5.3

1.30E − 07

5.80E − 05

Properdin

P27918

0.20

0.04

5.3

1.70E − 07

7.30E − 05

Serum amyloid A-4 protein

P35542

0.19

0.04

5.2

2.20E − 07

9.90E − 05

Kallistatin

P29622

− 0.19

0.04

− 5.2

2.70E − 07

1.20E − 04

ADAMTS-like protein 4

Q6UY14

− 0.19

0.04

 − 5.2

2.70E − 07

1.20E − 04

Limbic system-associated membrane protein

Q13449

− 0.19

0.04

− 5.2

3.00E − 07

1.30E − 04

Coagulation factor XIII A chain

P00488

− 0.18

0.04

− 5.1

5.00E − 07

2.20E − 04

Vascular cell adhesion protein 1

P19320

− 0.19

0.04

− 5.0

7.50E − 07

3.30E − 04

Cholinesterase

P06276

0.21

0.04

5.0

9.00E − 07

3.90E − 04

Endoglin

P17813

− 0.18

0.04

− 5.0

9.40E − 07

4.10E − 04

Fibulin-1

P23142

− 0.18

0.04

− 4.9

1.20E − 06

5.30E − 04

Insulin-like growth factor-binding protein 2

P18065

− 0.18

0.04

− 4.9

1.50E − 06

6.50E − 04

Mast/stem cell growth factor receptor kit

P10721

− 0.18

0.04

− 4.8

1.60E − 06

7.10E − 04

Serum amyloid A-1 protein

P0DJI8

0.18

0.04

4.8

1.80E − 06

8.00E − 04

Inter-alpha-trypsin inhibitor heavy chain H1

P19827

− 0.18

0.04

− 4.8

2.10E − 06

9.20E − 04

Transthyretin

P02766

− 0.19

0.04

− 4.8

2.20E − 06

9.50E − 04

Serum amyloid A-2 protein

P0DJI9

0.18

0.04

4.8

2.20E − 06

9.70E − 04

C4b-binding protein beta chain

P20851

0.18

0.04

4.7

3.90E − 06

1.70E − 03

Protein S100-A9

P06702

0.16

0.04

4.6

4.60E − 06

2.00E − 03

Transforming growth factor-beta-induced protein ig-h3

Q15582

− 0.17

0.04

− 4.6

6.10E − 06

2.70E − 03

Gelsolin

P06396

− 0.18

0.04

− 4.5

6.90E − 06

3.00E − 03

Complement component C8 gamma chain

P07360

0.17

0.04

4.4

1.00E − 05

4.60E − 03

Cadherin-13

P55290

− 0.17

0.04

− 4.4

1.10E − 05

4.60E − 03

Voltage-dependent calcium channel subunit alpha-2/delta-1

P54289

− 0.16

0.04

− 4.4

1.60E − 05

6.80E − 03

Apolipoprotein A-IV

P06727

− 0.17

0.04

− 4.3

1.80E − 05

8.00E − 03

Serum paraoxonase/lactonase 3

Q15166

− 0.16

0.04

− 4.3

2.20E − 05

9.40E − 03

Basement membrane-specific heparan sulfate proteoglycan core protein

P98160

− 0.16

0.04

− 4.3

2.20E − 05

9.80E − 03

Transketolase

P29401

0.16

0.04

4.2

2.80E − 05

1.20E − 02

ADAM DEC1

O15204

− 0.15

0.03

− 4.2

3.00E − 05

1.30E − 02

Gamma-glutamyl hydrolase

Q92820

0.15

0.04

4.2

3.10E − 05

1.40E − 02

4F2 cell-surface antigen heavy chain

P08195

− 0.16

0.04

− 4.2

3.50E − 05

1.50E − 02

SPARC-like protein 1

Q14515

− 0.15

0.04

− 4.2

3.60E − 05

1.60E − 02

Complement factor H-related protein 1

Q03591

0.15

0.04

4.1

4.00E − 05

1.70E − 02

Bone marrow proteoglycan

P13727

− 0.15

0.04

− 4.1

4.00E − 05

1.80E − 02

Apolipoprotein A-II

P02652

− 0.15

0.04

− 4.1

4.70E − 05

2.10E − 02

Adiponectin

Q15848

− 0.15

0.04

− 4.1

4.70E − 05

2.10E − 02

Neural cell adhesion molecule L1-like protein

O00533

− 0.16

0.04

− 4.1

4.90E − 05

2.20E − 02

Complement C3

P01024

0.15

0.04

4.1

5.10E − 05

2.30E − 02

Complement factor B

P00751

0.15

0.04

4.1

5.50E − 05

2.40E − 02

Insulin-like growth factor I

P05019

− 0.15

0.04

− 4.0

6.00E − 05

2.60E − 02

Prolow-density lipoprotein receptor-related protein 1

Q07954

− 0.15

0.04

− 4.0

6.60E − 05

2.90E − 02

Fructose-bisphosphate aldolase B

P05062

0.14

0.04

4.0

7.20E − 05

3.20E − 02

Vitamin D-binding protein

P02774

− 0.15

0.04

− 4.0

7.80E − 05

3.40E − 02

Carboxypeptidase N catalytic chain

P15169

− 0.16

0.04

− 3.9

8.70E − 05

3.80E − 02

Neural cell adhesion molecule 1

P13591

− 0.15

0.04

− 3.9

9.70E − 05

4.30E − 02

Metalloproteinase inhibitor 2

P16035

− 0.14

0.04

− 3.9

1.00E − 04

4.60E − 02

  1. Protein estimates whose abundance were significantly associated with body mass index are shown if Bonferroni-corrected coefficient null-test p-values were less than 0.05. Mixed-effects models included as covariates: age at blood sampling, age squared, sex, and interactions of sex with age and age squared. Random effects included the zygosity indicator variable and family identifiers. Body mass index was z-scored; fixed effects estimates indicate effect on 1 sd change
  2. se Standard error