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Fig. 1 | BMC Medicine

Fig. 1

From: Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns

Fig. 1

The workflow of this study. a. MSN construction. The 308 × 308 matrix for MSN was calculated across multiple macrostructural features (surface area, cortical thickness, gray matter volume, Gaussian curvature, and mean curvature). The MSN strength was obtained by the average weighted correlation coefficients between a given region and all other regions. b. Classification. The HYDRA method was used to identify EOS subtypes within the MSN strength. c. EOS-related gene analysis. PLS regression was then used to identify imaging transcriptomic associations. The link between brain-wide gene expression and morphometric changes in different EOS subtypes was evaluated through PLS weight mapping, genetic commonalities evaluation with psychiatric disorders, functional enrichment of PLS weighted genes, and cellular transcriptional signature assessment

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BMC Medicine

ISSN: 1741-7015

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