Table 3 Results of the 2 sample Mendelian randomisation analysis using MRLap for mental health outcome for all participants and stratified by sex. Results represent odds ratio or betas per standard deviation change in genetically instrumented sedentary time

Exposure

Outcome

Strata

OR (95% CI)

P

 Sedentary time

PGC-Depression

All

0.96 (0.86; 1.07)

4.38E − 01

 Sedentary time

PGC-Anxiety

All

2.25 (1.10; 4.60)

2.59E − 02

Exposure

Outcome

Strata

Odds ratio (95% CI)

P

 Sedentary time

Current depression

All

0.95 (0.84; 1.07)

4.01E − 01

Females

0.96 (0.82; 1.12)

5.97E − 01

Males

0.94 (0.76; 1.16)

5.80E − 01

 Sedentary time

Lifetime major depression

All

1.06 (0.93; 1.20)

3.97E − 01

Females

1.08 (0.92; 1.26)

3.62E − 01

Males

1.02 (0.85; 1.22)

8.41E − 01

 Sedentary time

Current anxiety disorder

All

0.98 (0.83; 1.15)

7.55E − 01

Females

0.88 (0.71; 1.08)

2.15E − 01

Males

1.13 (0.88; 1.44)

3.43E − 01

 Sedentary time

Lifetime anxiety disorder

All

0.97 (0.83; 1.12)

6.34E − 01

Females

0.95 (0.78; 1.17)

6.47E − 01

Males

0.99 (0.79; 1.25)

9.50E − 01

Exposure

Outcome

Strata

Beta (SE)

P

 Sedentary time

Well-being

All

 − 0.18 (− 0.33; − 0.04)

1.46E − 02

Females

 − 0.14 (− 0.31; 0.03)

1.14E − 01

Males

 − 0.23 (− 0.44; − 0.02)

2.91E − 02

 Sedentary time

Severity of major depression

All

0.08 (− 0.06; 0.22)

2.47E − 01

Females

0.04 (− 0.12; 0.20)

6.26E − 01

Males

0.14 (− 0.09; 0.37)

2.43E − 01

 Sedentary time

Severity of current depression

All

0.05 (− 0.08; 0.18)

4.69E − 01

Females

0.06 (− 0.11; 0.23)

4.73E − 01

Males

0.03 (− 0.16; 0.22)

7.60E − 01

 Sedentary time

Severity of anxiety

All

0.004 (− 0.12; 0.13)

9.52E − 01

Females

0.04 (− 0.12; 0.20)

6.12E − 01

Males

 − 0.02 (− 0.22; 0.17)

8.12E − 01

 Sedentary time

Subjective well-being (GWAS)

All

0.10 (− 0.35; 0.56)

6.59E − 01