Table 4 Results of the 2 sample Mendelian randomisation analysis using depression, anxiety and well-being as predictors for all participants and stratified by sex. Results represent betas per standard deviation change in genetically instrumented risk of of the exposures
Exposure | Outcome | Strata | Beta (95% CI) | P |
Depression | Overall physical activity | All | − 0.25 (− 0.42; − 0.08) | 4.07E − 03 |
Females | − 0.45 (− 0.67; − 0.23) | 6.05E − 05 | ||
Males | − 0.08 (− 0.27; 0.11) | 4.21E − 01 | ||
Depression | Sedentary time | All | 0.04 (− 0.11; 0.18) | 6.33E − 01 |
Females | 0.17 (− 0.03; 0.36) | 9.32E − 02 | ||
Males | − 0.08 (− 0.28; 0.12) | 4.13E − 01 | ||
Exposure | Outcome | Strata | Beta (95% CI) | P |
Anxiety | Overall physical activity | All | 0.00 (− 0.08; 0.08) | 9.48E − 01 |
Females | 0.01 (− 0.10; 0.10) | 8.24E − 01 | ||
Males | − 0.01 (-0.11; 0.10) | 8.99E − 01 | ||
Anxiety | Sedentary time | All | − 0.02 (− 0.13; 0.08) | 9.99E − 01 |
Females | − 0.04 (− 0.18; 0.09) | 5.34E − 01 | ||
Males | 0.00 (− 0.13; 0.12) | 9.46E − 01 | ||
Exposure | Outcome | Strata | Beta (95% CI) | P |
Well-being GWAS | Overall physical activity | All | 0.13 (− 0.06; 0.31) | 1.68E − 01 |
Females | 0.07 (− 0.17; 0.31) | 5.71E − 01 | ||
Males | 0.16 (− 0.04; 0.36) | 1.21E − 01 | ||
Well-being GWAS | Sedentary time | All | 0.07 (− 0.09; 0.23) | 3.87E − 01 |
Females | 0.05 (− 0.18; 0.28) | 6.54E − 01 | ||
Males | 0.10 (− 0.10; 0.29) | 3.27E − 01 | ||
Well-being from UKB | Overall physical activity | All | 0.15 (0.05; 0.25) | 4.65E − 03 |
Females | 0.18 (0.04; 0.33) | 1.33E − 02 | ||
Males | 0.12 (− 0.002; 0.24) | 5.40E − 02 | ||
Well-being from UKB | Sedentary time | All | − 0.02 (− 0.12; 0.09) | 7.14E − 01 |
Females | − 0.05 (− 0.19; 0.09) | 4.75E − 01 | ||
Males | 0.00 (− 0.12; 0.12) | 9.87E − 01 |