Table 1 Demographic and clinical data of acute type A aortic dissection patients whose samples were sent for plasma proteomics
Variables | Overall (n = 30) | ASA-AKI (n = 15) | Non-ASA-AKI (n = 15) | p-value |
|---|---|---|---|---|
Preoperative parameters | ||||
 Demographics | ||||
  Age (year) | 63.3 ± 14.3 | 62.6 ± 13.3 | 64.1 ± 15.6 | 0.784 |
  Male (%) | 21 (70.0) | 10 (66.7) | 11 (73.3) | 0.690 |
  BMI (kg/m2) | 23.9 ± 3.4 | 24.6 ± 3.0 | 23.3 ± 3.7 | 0.289 |
 Tobacco use (%) | 11 (36.7) | 6 (40.0) | 5 (33.3) | 0.705 |
 Medical history | ||||
  Hypertension (%) | 27 (90.0) | 13 (86.7) | 14 (93.3) | 1.000 |
  Diabetes mellitus (%) | 2 (6.7) | 1 (6.7) | 1 (6.7) | 1.000 |
  Previous cardiac surgery (%) | 2 (6.7) | 1 (6.7) | 1 (6.7) | 1.000 |
  Cerebrovascular disease (%) | 7 (23.3) | 3 (20.0) | 4 (26.7) | 1.000 |
  Coronary artery disease (%) | 1 (3.3) | 0 (0) | 1 (6.7) | 1.000 |
  CKD (%) | 3 (10.0) | 2 (13.3) | 1 (6.7) | 1.000 |
   CKD stage 1 (%) | 2 (6.7) | 1 (6.7) | 1 (6.7) | 1.000 |
   CKD stage 2 (%) | 1 (3.3) | 1 (6.7) | 0 (0) | 1.000 |
 LVEF (%) | 57.0 ± 3.0 | 57.3 ± 3.0 | 56.7 ± 3.1 | 0.592 |
 Involving renal artery (%) | 19 (63.3) | 10 (66.7) | 9 (60.0) | 0.705 |
 Left renal artery | ||||
  True lumen (%) | 17 (56.7) | 7 (46.7) | 10 (66.7) |  |
  False lumen (%) | 5 (16.7) | 3 (20.0) | 2 (13.3) |  |
  True and false lumen (%) | 8 (26.7) | 5 (33.3) | 3 (20.0) | 0.605 |
 Right renal artery | ||||
  True lumen (%) | 19 (63.3) | 8 (53.3) | 11 (73.3) |  |
  False lumen (%) | 5 (16.7) | 2 (13.3) | 3 (20.0) |  |
  True and false lumen (%) | 6 (20.0) | 5 (33.3) | 1 (6.7) | 0.250 |
 Preoperative laboratory results | ||||
  WBC (109/L) | 10.5 ± 3.2 | 10.1 ± 3.3 | 10.9 ± 3.2 | 0.543 |
  Hemoglobin (g/L) | 125.0 ± 23.6 | 120.9 ± 26.2 | 129.1 ± 20.7 | 0.346 |
  Creatinine (μmol/L) | 69.9 ± 20.7 | 72.7 ± 22.9 | 67.0 ± 18.7 | 0.479 |
  BUN (mmol/L) | 5.7 ± 1.8 | 5.5 ± 1.9 | 5.9 ± 1.8 | 0.583 |
  Cystatin C (mg/L) | 0.8 ± 0.4 | 0.9 ± 0.5 | 0.8 ± 0.4 | 0.625 |
  eGFR (ml/min) | 106.8 ± 20.1 | 104.0 ± 19.1 | 109.6 ± 21.3 | 0.454 |
  Albuminuria (%) | 2 (6.7) | 1 (6.7) | 1 (6.7) | 1.000 |
  D-Dimer (ng/mL) | 8.1 (2.6, 23.1) | 7.0 (2.4, 20.8) | 10.2 (6.5, 39.0) | 0.382 |
Intraoperative parameters | ||||
 CPB duration (min) | 186.3 ± 46.8 | 206.3 ± 49.2 | 166.3 ± 35.5 | 0.016 |
 Cross-clamp duration (min) | 140.4 ± 43.0 | 155.8 ± 47.3 | 125.1 ± 33.0 | 0.048 |
 Hypothermia circulation arrest time (min) | 25.2 ± 9.8 | 24.5 ± 7.4 | 25.9 ± 12.0 | 0.704 |
Postoperative parameters | ||||
 Drainage volume 24 h after surgery (ml) | 662.0 ± 278.9 | 775.3 ± 257.7 | 548.7 ± 259.1 | 0.023 |
 Dialysis (%) | 3 (10.0) | 3 (20.0) | 0 (0) | 0.224 |
 Cleveland Clinic score | 4.3 ± 1.6 | 5.1 ± 1.6 | 3.5 ± 1.3 | 0.006 |
 Mechanical ventilation time (h) | 20.8 (16.0, 34.6) | 34.5 (17.0, 76.5) | 15.5 (15.0, 26.0) | 0.032 |
 In-hospital death (%) | 3 (10.0) | 2 (13.3) | 1 (6.7) | 1.000 |
 ICU stay (days) | 5.0 (3.0, 8.3) | 5.0 (4.0, 9.0) | 4.0 (3.0, 6.0) | 0.005 |
 Hospital stay (days) | 17.0 (13.0, 22.3) | 17.0 (14.0, 24.0) | 15.0 (11.0, 18.0) | 0.004 |