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Table 3 Univariate and multivariate analysis results

From: Prediction of acute kidney injury incidence following acute type A aortic dissection surgery with novel biomarkers: a prospective observational study

Variables

Univariate analysis

Multivariate analysisa

OR (95% CI)

p-value

OR (95% CI)

p-value

Age

1.01 (0.99–1.03)

0.557

1.07 (1.02–1.13)

0.005

BMI

1.03 (0.98, 1.10)

0.258

1.12 (0.96–1.31)

0.164

Pre-admission CKD

10.17 (2.78–65.62)

0.002

10.95 (0.91–296.32)

0.087

Preoperative serum creatinine

1.01 (1.01–1.02)

0.002

1.01 (1.00–1.03)

0.316

Preoperative eGFR

0.99 (0.98–1.00)

0.032

1.00 (0.98–1.02)

0.698

Preoperative cystatin C

2.54 (1.30–5.06)

0.007

2.70 (0.59–13.75)

0.211

Preoperative WBC

1.17 (1.08–1.28)

 < 0.001

1.31 (1.11–1.56)

0.002

Preoperative D-dimer

1.00 (0.99, 1.01)

0.977

0.99 (0.96–1.01)

0.283

CPB duration > 180 min

4.10 (2.35–7.33)

 < 0.001

3.10 (1.13, 8.96)

0.031

Drainage volume 24 h after surgery

1.00 (1.00–1.00)

0.032

1.00 (1.00–1.00)

0.758

Cleveland Clinic score

1.30 (1.15–1.46)

 < 0.001

1.26 (1.02–1.58)

0.037

Urinary NGAL 0 h post-surgery

1.01 (1.01–1.02)

 < 0.001

1.02 (1.01–1.03)

 < 0.001

Plasma S100A8/A9 0 h post-surgery

1.35 (1.24–1.49)

 < 0.001

1.33 (1.18–1.54)

 < 0.001

Plasma PTX3 0 h post-surgery

1.25 (1.17–1.35)

 < 0.001

1.25 (1.13–1.41)

 < 0.001

Plasma CHI3L1 0 h post-surgery

1.01 (1.00–1.01)

 < 0.001

1.01 (1.00–1.01)

 < 0.001

  1. aAdjustment was made for various categories including demographics (such as age and BMI), comorbidities (like pre-admission CKD status), baseline renal function (eGFR, serum creatinine, and cystatin C), laboratory values (for example, WBC and D-dimer), intraoperative variables (such as time of CPB), and postoperative risk factors (including drainage volume 24 h after surgery, Cleveland Clinic score, and biomarker levels 0 h post-surgery)
  2. BMI Body mass index, CKD Chronic kidney disease, eGFR estimated glomerular filtration rate, WBC White blood cell, CPB Cardiopulmonary bypass, NGAL Neutrophil gelatinase-associated lipocalin, PTX3 Pentraxin 3, CHI3L1 Chitinase 3-like 1, OR Odds ratio, CI Confidence interval