Fig. 1

Overview of the 247,684 single cells isolated from ARVC and NC human hearts. A Workflow of the present study. B UMAP plots of the 247,684 cells colored according to the 13 major cell types, two phases, and 8 patients (left to right). C Expression of classic marker genes used to define the major cell types. D Dendrogram demonstrating the similarity of cluster centroids. E Cell numbers of each of the 13 major cell types. F Stacked bar plot depicting the cell-type composition of each sample. UMAP, uniform manifold approximation and projection; ARVC, arrhythmogenic right ventricular cardiomyopathy; NC, normal control; AC_LV, left ventricle of ARVC; AC_RV, right ventricle of ARVC; NC_LV, left ventricle of NC; NC_RV, right ventricle of NC; AC_PBMC, PBMC of ARVC; PBMC, peripheral blood mononuclear cell; NK, natural killer; NP, neutrophils; VSMC, vascular smooth muscle cell