Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants

Table 3 Associations between lifetime duration of night shift work and the risk of incident COPD (n = 74,559)

Variables	HR (95% CI) by lifetime duration of night shift work			P for trend
Variables	None	< 10 years	≥ 10 years	P for trend
Case/all subjects	805/56,698	176/9673	164/8188
Model 1	1 [reference]	1.28 (1.09, 1.51)	1.42 (1.20, 1.67)	< 0.001
Model 2	1 [reference]	1.33 (1.13, 1.57)	1.48 (1.25, 1.75)	< 0.001
Model 3	1 [reference]	1.18 (1.00, 1.39)	1.22 (1.03, 1.45)	0.007
Model 4	1 [reference]	1.17 (1.00, 1.38)	1.23 (1.03, 1.46)	0.007

Abbreviations: COPD Chronic obstructive pulmonary disease, BMI Body mass index, IPAQ International Physical Activity Questionnaire
Model 1: Unadjusted
Model 2: Model 1 + age and sex
Model 3: Model 2 + ethnicity, BMI, Townsend deprivation index, sleep duration, smoking status, alcohol drinking, IPAQ activity group, and chronotype
Model 4: Model 3 + asthma

ISSN: 1741-7015