Table 1 Characteristics of the randomized patients at baseline
Characteristic | Amlodipine/benazepril (n = 213) | Benazepril/hydrochlorothiazide (n = 212) | p value |
|---|---|---|---|
Men (n, %) | 123 (57.8) | 130 (61.3) | 0.45 |
Age (years) | 54.2 ± 12.0 | 53.6 ± 11.7 | 0.64 |
Body mass index (kg/m2) | 25.0 ± 3.1 | 25.2 ± 2.8 | 0.67 |
Previous antihypertensive treatment (n, %) | 71 (33.3) | 68 (32.1) | 0.78 |
Angiotensin-converting enzyme inhibitors | 14 (6.6) | 16 (7.6) | 0.70 |
Angiotensin receptor blockers | 18 (8.5) | 20 (9.4) | 0.72 |
Calcium-channel blockers | 32 (15.0) | 27 (12.7) | 0.50 |
Diuretics | 5 (2.4) | 2 (0.9) | 0.26 |
Others | 2 (0.9) | 3 (1.4) | 0.65 |
Diabetes mellitus (n, %) | 9 (4.2) | 9 (4.3) | 0.99 |
Chronic kidney disease (n, %) | 2 (0.9) | 4 (1.9) | 0.41 |
Clinic blood pressure (mmHg) | |||
Systolic | 150.9 ± 7.4 | 151.2 ± 8.8 | 0.75 |
Diastolic | 92.7 ± 5.4 | 92.5 ± 5.7 | 0.68 |
Clinic pulse rate (beats/min) | 75.2 ± 7.4 | 75.2 ± 7.9 | 0.96 |
Ambulatory blood pressure (mmHg) | |||
24-h systolic | 143.5 ± 14.1 | 142.8 ± 13.4 | 0.58 |
24-h diastolic | 85.9 ± 8.8 | 86.1 ± 10.1 | 0.70 |
Daytime systolic | 148.0 ± 14.9 | 146.7 ± 14.7 | 0.34 |
Daytime diastolic | 88.8 ± 9.8 | 88.6 ± 11.1 | 0.83 |
Nighttime systolic | 133.8 ± 17.7 | 133.3 ± 16.8 | 0.77 |
Nighttime diastolic | 79.4 ± 10.0 | 79.8 ± 11.2 | 0.67 |
Home blood pressure (mmHg) | n = 125 | n = 119 | |
Systolic | 148.6 ± 18.7 | 148.6 ± 8.7 | 0.95 |
Diastolic | 89.4 ± 6.5 | 89.2 ± 8.0 | 0.80 |