Variable | All-cause dementia | Alzheimer’s disease | Vascular dementia | ||||||
---|---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |
Central obesity | |||||||||
 No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 Yes | 1.15 (1.10–1.21)* | 1.03 (0.98–1.08) | 1.00 (0.96–1.06) | 1.00 (0.92–1.07) | 0.91 (0.85–0.99) | 0.90 (0.83–0.98) | 1.44 (1.30–1.60)* | 1.25 (1.13–1.39)* | 1.18 (1.06–1.31)* |
Dyslipidemia for HDL cholesterol | |||||||||
 No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 Yes | 1.29 (1.22–1.37)* | 1.11 (1.04–1.18)* | 1.07 (1.01–1.14)* | 1.19 (1.08–1.30)* | 1.04 (0.95–1.15) | 1.02 (0.93–1.13) | 1.62 (1.43–1.82)* | 1.33 (1.17–1.51)* | 1.24 (1.09–1.41)* |
Hypertension | |||||||||
 No | 1.00 (Ref) | 1.00 Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 Yes | 1.13 (1.05–1.21)* | 1.12 (1.04–1.2)* | 1.09 (1.02–1.17)* | 1.16 (1.04–1.29)* | 1.16 (1.03–1.29)* | 1.15 (1.03–1.28)* | 1.44 (1.22–1.70)* | 1.42 (1.20–1.68)* | 1.33 (1.12–1.58)* |
Hyperglycemia | |||||||||
 No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 Yes | 1.59 (1.50–1.68)* | 1.48 (1.40–1.57)* | 1.4 (1.35–1.51)* | 1.38 (1.26–1.50)* | 1.30 (1.19–1.42)* | 1.27 (1.16–1.39)* | 2.26 (2.02–2.52)* | 2.03 (1.81–2.27)* | 1.85 (1.65–2.07)* |
Dyslipidemia for triglycerides | |||||||||
 No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 Yes | 1.20 (1.14–1.27)* | 1.12 (1.06–1.18)* | 1.05 (1.00–1.11)* | 1.16 (1.07–1.26)* | 1.09 (1.01–1.19)* | 1.06 (0.97–1.15) | 1.65 (1.47–1.86)* | 1.51 (1.34–1.70)* | 1.33 (1.17–1.50)* |
Number of MetS components | |||||||||
 0 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
 1 | 1.19 (1.06–1.34)* | 1.19 (1.06–1.34)* | 1.19 (1.06–1.34)* | 1.23 (1.02–1.46)* | 1.23 (1.02–1.47)* | 1.23 (1.03–1.47)* | 1.50 (1.10–2.04)* | 1.49 (1.09–2.04)* | 1.48 (1.08–2.02)* |
 2 | 1.23 (1.09–1.38)* | 1.19 (1.06–1.34)* | 1.16 (1.03–1.30)* | 1.19 (1.00–1.42)* | 1.17 (0.98–1.41) | 1.16 (0.97–1.39) | 1.73 (1.27–2.34)* | 1.66 (1.22–2.26)* | 1.55 (1.14–2.11)* |
 3 | 1.40 (1.25–1.58)* | 1.27 (1.13–1.43)* | 1.20 (1.07–1.36)* | 1.36 (1.13–1.62)* | 1.26 (1.05–1.51)* | 1.22 (1.01–1.47)* | 2.22 (1.63–3.01)* | 1.96 (1.43–2.67)* | 1.73 (1.27–2.37)* |
 4 | 1.66 (1.46–1.88)* | 1.42 (1.25–1.61)* | 1.32 (1.16–1.50)* | 1.43 (1.18–1.74)* | 1.27 1.04–1.55)* | 1.22 (1.00–1.49)* | 3.02 (2.20–4.13)* | 2.52 (1.83–3.46)* | 2.14 (1.55–2.96)* |
 5 | 2.49 (2.15–2.88)* | 1.95 (1.68–2.26)* | 1.76 (1.51–2.04)* | 1.97 (1.56–2.48)* | 1.63 (1.28–2.06)* | 1.53 (1.20–1.94)* | 6.28 (4.51–8.74)* | 4.67 (3.33–6.56)* | 3.72 (2.64–5.24)* |
 | p trend <0.001 | p trend <0.001 | p trend <0.001 | p trend <0.001 | p trend =0.002 | p trend =0.029 | p trend <0.001 | p trend <0.001 | p trend <0.001 |